Source:http://linkedlifedata.com/resource/umls/id/C0054959
MSH: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.,CSP: 50 kD glycoprotein expressed on all B cells; plays an important role in B cell development and activation.,NCI: Tumor necrosis factor receptor superfamily member 5 (277 aa, 31 kD) is a cell fate protein that is encoded by the human CD40 gene and has roles in inflammatory response, B-cell proliferation and apoptosis.