rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6587
|
pubmed:dateCreated |
1996-8-30
|
pubmed:abstractText |
Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0028-0836
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
11
|
pubmed:volume |
382
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
133-8
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:8700202-Animals,
pubmed-meshheading:8700202-Base Sequence,
pubmed-meshheading:8700202-DNA,
pubmed-meshheading:8700202-DNA Footprinting,
pubmed-meshheading:8700202-Drosophila,
pubmed-meshheading:8700202-Drosophila Proteins,
pubmed-meshheading:8700202-Enhancer Elements, Genetic,
pubmed-meshheading:8700202-Gene Expression Regulation, Developmental,
pubmed-meshheading:8700202-Insect Hormones,
pubmed-meshheading:8700202-Molecular Sequence Data,
pubmed-meshheading:8700202-Nuclear Proteins,
pubmed-meshheading:8700202-Repressor Proteins,
pubmed-meshheading:8700202-Signal Transduction,
pubmed-meshheading:8700202-Wing
|
pubmed:year |
1996
|
pubmed:articleTitle |
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.
|
pubmed:affiliation |
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|