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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0017262,
umls-concept:C0024660,
umls-concept:C0033684,
umls-concept:C0079429,
umls-concept:C0185117,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1334043,
umls-concept:C1420744,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1704259,
umls-concept:C1705248,
umls-concept:C1705987,
umls-concept:C2700640,
umls-concept:C2911684
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pubmed:issue |
14
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pubmed:dateCreated |
1996-9-5
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pubmed:databankReference |
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pubmed:abstractText |
In Drosophila sensory organ development, the balance of activities between proneural genes and repressor genes defines a proneural cluster as a population of competent cells for neural development. In this study, we report the isolation and analysis of the tamou (tam) gene that encodes a cell-cell junction-associated protein, which is homologous to mammalian ZO-1, a member of the membrane-associated guanylate kinase homolog family. The tam mutation reduces the transcription of a repressor gene, extramacrochaetae, and causes enlargement of a proneural cluster where supernumerary precursor cells emerge, resulting in extra mechanosensory organs in the fly. These results suggest that the membrane-associated Tam protein is involved in the signaling pathway that activates emc expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/emc protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/zonula occludens-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/zonula occludens-2 protein
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1783-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8698238-Amino Acid Sequence,
pubmed-meshheading:8698238-Animals,
pubmed-meshheading:8698238-Animals, Genetically Modified,
pubmed-meshheading:8698238-Base Sequence,
pubmed-meshheading:8698238-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:8698238-Cell Division,
pubmed-meshheading:8698238-Chromosome Mapping,
pubmed-meshheading:8698238-DNA, Complementary,
pubmed-meshheading:8698238-DNA-Binding Proteins,
pubmed-meshheading:8698238-Drosophila,
pubmed-meshheading:8698238-Drosophila Proteins,
pubmed-meshheading:8698238-Genes, Insect,
pubmed-meshheading:8698238-Intercellular Junctions,
pubmed-meshheading:8698238-Membrane Proteins,
pubmed-meshheading:8698238-Molecular Sequence Data,
pubmed-meshheading:8698238-Mutation,
pubmed-meshheading:8698238-Phenotype,
pubmed-meshheading:8698238-Phosphoproteins,
pubmed-meshheading:8698238-RNA,
pubmed-meshheading:8698238-Repressor Proteins,
pubmed-meshheading:8698238-Sense Organs,
pubmed-meshheading:8698238-Sequence Homology, Amino Acid
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pubmed:year |
1996
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pubmed:articleTitle |
The Drosophila tamou gene, a component of the activating pathway of extramacrochaetae expression, encodes a protein homologous to mammalian cell-cell junction-associated protein ZO-1.
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pubmed:affiliation |
Mitsubishi Kasei Institute of Life Sciences, Machida-shi, Tokyo 194, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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