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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0039194,
umls-concept:C0111208,
umls-concept:C0206527,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1332709,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1996-11-25
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pubmed:abstractText |
Co-stimulation via the CD28/CTLA-4 system appears critical for T cell proliferation to peptide antigens presented in association with MHC. In this study, we examine the roles of CD28 and CTLA-4 in the response of murine T cells to the superantigen staphylococcal enterotoxin B (SEB). In vitro, antibodies against B7-1/B7-2 or Fab fragments of anti-CD28 antibodies significantly inhibit the response of splenocytes to SEB. Conversely, Fab fragments of anti-CTLA-4 antibodies augment the proliferative response. Further, addition of blocking antibodies directed against B7-1/B7-2 augment proliferation co-stimulated by intact anti-CD28 antibodies. These data support the hypothesis that CD28 and CTLA-4 exert opposing effects upon early T cell activation. In vivo, intact anti-CD28 antibodies and non-stimulatory Fab fragments of anti-CD28 appear to have similar inhibitory effects upon the expansion of V beta 8+ T cells. In contrast, both intact and Fab fragments of anti-CTLA-4 appear to amplify this expansion. We conclude that the SEB response is significantly augmented by CD28-derived signaling and this in turn may be attenuated by signals through CTLA-4.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Blocking,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fab Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-23
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8671638-Animals,
pubmed-meshheading:8671638-Antibodies, Blocking,
pubmed-meshheading:8671638-Antigen Presentation,
pubmed-meshheading:8671638-Antigens, CD,
pubmed-meshheading:8671638-Antigens, CD28,
pubmed-meshheading:8671638-Antigens, CD80,
pubmed-meshheading:8671638-Antigens, Differentiation,
pubmed-meshheading:8671638-CTLA-4 Antigen,
pubmed-meshheading:8671638-Cell Division,
pubmed-meshheading:8671638-Cells, Cultured,
pubmed-meshheading:8671638-Enterotoxins,
pubmed-meshheading:8671638-Immunoconjugates,
pubmed-meshheading:8671638-Immunoglobulin Fab Fragments,
pubmed-meshheading:8671638-Mice,
pubmed-meshheading:8671638-Mice, Inbred BALB C,
pubmed-meshheading:8671638-Superantigens,
pubmed-meshheading:8671638-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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