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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0017337,
umls-concept:C0027893,
umls-concept:C0074830,
umls-concept:C0079633,
umls-concept:C0205314,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0597357,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C1283195,
umls-concept:C1332822,
umls-concept:C1540171,
umls-concept:C1547699,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1706328,
umls-concept:C1826696,
umls-concept:C2700640
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pubmed:issue |
2
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pubmed:dateCreated |
1996-8-7
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pubmed:databankReference |
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pubmed:abstractText |
We employed the polymerase chain reaction and genomic DNA library screening to clone novel human genes, GPR9 and GPR10, and a rat gene, GPR14. GPR9, GPR10, and GPR14 each encode G protein-coupled receptors. GPR10 and GPR14 are intronless within their coding regions, while GPR9 contains at least one intron. The receptor encoded by GPR9 shares the highest identity with human IL-8 receptor type B (38% overall and 53% in the transmembrane regions), followed by IL-8 receptor type A (36% overall and 51% in the transmembrane domains). GPR10 encodes a receptor that shares highest identity with the neuropeptide Y receptor (31% overall and 46% in the transmembrane domains). The receptor encoded by GPR14 shares highest identity with the somatostatin receptor SSTR 4 (27% overall and 41% in the transmembrane domains). Fluorescence in situ hybridization analysis localized GPR9 to chromosome 8p11.2-p12 and GPR10 to chromosome 10q25.3-q26.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-8A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neuropeptide Y,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
335-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8666380-Amino Acid Sequence,
pubmed-meshheading:8666380-Antigens, CD,
pubmed-meshheading:8666380-Base Sequence,
pubmed-meshheading:8666380-Blotting, Northern,
pubmed-meshheading:8666380-Brain,
pubmed-meshheading:8666380-Chromosome Mapping,
pubmed-meshheading:8666380-Chromosomes, Human, Pair 8,
pubmed-meshheading:8666380-Cloning, Molecular,
pubmed-meshheading:8666380-DNA,
pubmed-meshheading:8666380-Gene Library,
pubmed-meshheading:8666380-Humans,
pubmed-meshheading:8666380-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8666380-Interleukin-8,
pubmed-meshheading:8666380-Lymphocytes,
pubmed-meshheading:8666380-Molecular Sequence Data,
pubmed-meshheading:8666380-Polymerase Chain Reaction,
pubmed-meshheading:8666380-RNA, Messenger,
pubmed-meshheading:8666380-Receptors, Interleukin,
pubmed-meshheading:8666380-Receptors, Interleukin-8A,
pubmed-meshheading:8666380-Receptors, Neuropeptide Y,
pubmed-meshheading:8666380-Receptors, Opioid,
pubmed-meshheading:8666380-Receptors, Somatostatin,
pubmed-meshheading:8666380-Recombinant Proteins,
pubmed-meshheading:8666380-Sequence Homology, Amino Acid
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pubmed:year |
1995
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pubmed:articleTitle |
Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.
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pubmed:affiliation |
Addiction Research Foundation, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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