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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-7-26
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pubmed:abstractText |
The current study was designed to investigate the influence of pretreatment with the oxygen radical scavengers polyethylene glycol superoxide dismutase and catalase (SODCAT) on altered opioid-induced pial artery dilation after fluid percussion brain injury (FPI) in the newborn pig. It has been observed previously that brain injury produces pial artery vasoconstriction in the piglet associated with elevated cerebrospinal fluid opioid levels. Furthermore, opioid-induced vasodilation and cyclic guanosine monophosphate production are attenuated following brain injury. Finally, oxygen free radicals have been implicated in the pathogenesis of brain injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
614-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8659790-Animals,
pubmed-meshheading:8659790-Blood Pressure,
pubmed-meshheading:8659790-Brain Injuries,
pubmed-meshheading:8659790-Catalase,
pubmed-meshheading:8659790-Cerebral Arteries,
pubmed-meshheading:8659790-Dynorphins,
pubmed-meshheading:8659790-Female,
pubmed-meshheading:8659790-Free Radical Scavengers,
pubmed-meshheading:8659790-Male,
pubmed-meshheading:8659790-Opioid Peptides,
pubmed-meshheading:8659790-Polyethylene Glycols,
pubmed-meshheading:8659790-Superoxide Dismutase,
pubmed-meshheading:8659790-Swine,
pubmed-meshheading:8659790-Vasodilation
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pubmed:year |
1996
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pubmed:articleTitle |
Influence of polyethylene glycol superoxide dismutase/catalase on altered opioid-induced pial artery dilation after brain injury.
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pubmed:affiliation |
Deparment of Anesthesia, University of Pennsylvania, Philadelphia, 19104-4399, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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