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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-8-1
|
| pubmed:abstractText |
The present study asked whether partial amygdala kindling would affect the expression of conditioned fear-potentiated startle. Rats were conditioned to be fearful of a light. They were then stimulated bilaterally in the amygdala or hippocampus on 2 consecutive days (partial kindling). Rats were tested 24 hr later for fear-potentiated startle. Amygdala-kindled rats had exaggerated fear-potentiated startle compared to sham-kindled rats. Hippocampus-kindled rats also displayed fear-potentiated startle, but no greater than that of sham-kindled rats. Partial amygdala kindling induced c-fos messenger RNA (mRNA) expression, a marker for neuronal activation, throughout the limbic and neocortices. In contrast, partial hippocampus kindling induced c-fos mRNA in the hippocampus only. The data suggest that kindled-induced hyperexcitability of the amygdala and limbic cortices produced exaggerated conditioned fear-potentiated startle.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0735-7044
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
43-50
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8652071-Amygdala,
pubmed-meshheading:8652071-Animals,
pubmed-meshheading:8652071-Arousal,
pubmed-meshheading:8652071-Association Learning,
pubmed-meshheading:8652071-Brain Mapping,
pubmed-meshheading:8652071-Cerebral Cortex,
pubmed-meshheading:8652071-Conditioning, Classical,
pubmed-meshheading:8652071-Dominance, Cerebral,
pubmed-meshheading:8652071-Fear,
pubmed-meshheading:8652071-Gene Expression,
pubmed-meshheading:8652071-Hippocampus,
pubmed-meshheading:8652071-Kindling, Neurologic,
pubmed-meshheading:8652071-Limbic System,
pubmed-meshheading:8652071-Male,
pubmed-meshheading:8652071-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:8652071-RNA, Messenger,
pubmed-meshheading:8652071-Rats,
pubmed-meshheading:8652071-Rats, Sprague-Dawley,
pubmed-meshheading:8652071-Startle Reaction,
pubmed-meshheading:8652071-Synaptic Transmission
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Hyperexcitability: exaggerated fear-potentiated startle produced by partial amygdala kindling.
|
| pubmed:affiliation |
Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA. jrosen@udel.edu
|
| pubmed:publicationType |
Journal Article
|