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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-7-12
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pubmed:abstractText |
Hodgkin's disease (HD) shows rare neoplastic Hodgkin and Reed-Sternberg cells embedded in an abundant reactive infiltrate containing, among other cell types, neutrophilic granulocytes. Interleukin (IL)-8 is chemotactic for neutrophils. The expression of IL-8 was tested by in situ hybridization with 35S-labeled IL-8-specific RNA probes on 38 cases of HD. Reactive lesions, non-Hodgkin's lymphomas of B and T phenotype, and Langerhans cell histiocytosis served as controls. IL-8 expression was observed in Hodgkin and Reed-Sternberg cells in 3 of 33 cases of classical HD and in reactive cells in 20 of 33 HD cases as evidenced by combined isotopic in situ hybridization and immunohistology for the demonstration of cell-type-characteristic antigens or enzyme histochemistry for chloroacetate esterase. IL-8-positive cells were more numerous in cases of nodular sclerosing HD as compared with the mixed cellularity histotype (P = 0.01). The number of IL-8-positive cells and the density of neutrophils were positively correlated (P < 0. 01). In 5 cases of lymphocyte-predominant HD, IL-8 expression was not displayed. Non-Hodgkin's lymphoma cases contained IL-8 transcripts only in 1 of 23 cases in sparse reactive cells. In 4 of 7 cases of Langerhans cell histiocytosis, IL-8-specific signals were displayed in S100-negative cells. In conclusion, IL-8 expression in HD is largely confined to reactive cells and associated with infiltration by neutrophils. Elaboration of other cytokines by Hodgkin and Reed-Sternberg cells and reactive cells may explain the frequent expression of this cytokine in HD, particularly in the nodular sclerosing type.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1281554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1281615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1312061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1312411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1375198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1497091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1593855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1596893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1610217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1643627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1702929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1739130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1899427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-1921160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2183871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2454986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2648569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2668411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2677047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-2737606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-3010124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-3260265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-3261707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-6198355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-7513008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-7682880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8132812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8217820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8258721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8298133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8304236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8360485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8386741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8419336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8644863-8494046
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
148
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1229-36
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8644863-Cell Count,
pubmed-meshheading:8644863-Histiocytosis, Langerhans-Cell,
pubmed-meshheading:8644863-Hodgkin Disease,
pubmed-meshheading:8644863-Humans,
pubmed-meshheading:8644863-Interleukin-8,
pubmed-meshheading:8644863-Lymphoma, Non-Hodgkin,
pubmed-meshheading:8644863-Mycobacterium Infections,
pubmed-meshheading:8644863-Neutrophils,
pubmed-meshheading:8644863-Palatine Tonsil
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pubmed:year |
1996
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pubmed:articleTitle |
Interleukin-8 in Hodgkin's disease. Preferential expression by reactive cells and association with neutrophil density.
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pubmed:affiliation |
Institut für Pathologie, Klinikum Benjamin Franklin, Free University of Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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