| pubmed-article:8630519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0006558 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0033362 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:8630519 | lifeskim:mentions | umls-concept:C0175721 | lld:lifeskim |
| pubmed-article:8630519 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8630519 | pubmed:dateCreated | 1996-6-28 | lld:pubmed |
| pubmed-article:8630519 | pubmed:abstractText | Increased concentrations of proinsulin immunoreactive material (PIM) absolutely or relative to insulin is a characteristic finding in patients with non-insulin-dependent diabetes mellitus (NIDDM). The aim of this study was to test if 8 h or mild hyperglycemia (7-9 mmol/l) in healthy subjects could induce a preferential secretion of PIM from B cells. Serum concentrations of insulin, C-peptide and PIM were measured every 10 min during the 8 h of continuous glucose infusion in nine normal-weight healthy subjects without diabetes among their first-degree relatives. After a gradual rise in B-cell peptides, a steady state was reached. From 4 to 8 h no further difference in insulin, C-peptide or PIM concentration was found. Fasting PIM/C-peptide and PIM/insulin ratios of 0.5% and 2.3% increased during the glucose clamp to levels of 1.4% and 7.6%, respectively. Neither testing the regression slope nor comparing individual time points showed any significant difference for the PIM/C-peptide ratio from 2 to 8 h and for the PIM/insulin ratio from 3 to 8 h. These results do not support the hypothesis that an increased glucose drive per se results in an altered B-cell function with increasing PIM/C-peptide ratio. At least 8 h of mild hyperglycemia in healthy subjects does not progressively alter B-cell function. | lld:pubmed |
| pubmed-article:8630519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8630519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8630519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8630519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8630519 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8630519 | pubmed:issn | 0804-4643 | lld:pubmed |
| pubmed-article:8630519 | pubmed:author | pubmed-author:BinderCC | lld:pubmed |
| pubmed-article:8630519 | pubmed:author | pubmed-author:DinesenBB | lld:pubmed |
| pubmed-article:8630519 | pubmed:author | pubmed-author:RøderM EME | lld:pubmed |
| pubmed-article:8630519 | pubmed:author | pubmed-author:HartlingS GSG | lld:pubmed |
| pubmed-article:8630519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8630519 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:8630519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8630519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8630519 | pubmed:pagination | 197-200 | lld:pubmed |
| pubmed-article:8630519 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:meshHeading | pubmed-meshheading:8630519-... | lld:pubmed |
| pubmed-article:8630519 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8630519 | pubmed:articleTitle | Proinsulin, C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp. | lld:pubmed |
| pubmed-article:8630519 | pubmed:affiliation | Steno Diabetes Center, Gentofte, Denmark. | lld:pubmed |
| pubmed-article:8630519 | pubmed:publicationType | Journal Article | lld:pubmed |
