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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1996-6-28
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pubmed:abstractText |
Increased concentrations of proinsulin immunoreactive material (PIM) absolutely or relative to insulin is a characteristic finding in patients with non-insulin-dependent diabetes mellitus (NIDDM). The aim of this study was to test if 8 h or mild hyperglycemia (7-9 mmol/l) in healthy subjects could induce a preferential secretion of PIM from B cells. Serum concentrations of insulin, C-peptide and PIM were measured every 10 min during the 8 h of continuous glucose infusion in nine normal-weight healthy subjects without diabetes among their first-degree relatives. After a gradual rise in B-cell peptides, a steady state was reached. From 4 to 8 h no further difference in insulin, C-peptide or PIM concentration was found. Fasting PIM/C-peptide and PIM/insulin ratios of 0.5% and 2.3% increased during the glucose clamp to levels of 1.4% and 7.6%, respectively. Neither testing the regression slope nor comparing individual time points showed any significant difference for the PIM/C-peptide ratio from 2 to 8 h and for the PIM/insulin ratio from 3 to 8 h. These results do not support the hypothesis that an increased glucose drive per se results in an altered B-cell function with increasing PIM/C-peptide ratio. At least 8 h of mild hyperglycemia in healthy subjects does not progressively alter B-cell function.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0804-4643
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-200
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8630519-Adolescent,
pubmed-meshheading:8630519-Adult,
pubmed-meshheading:8630519-Aged,
pubmed-meshheading:8630519-Aged, 80 and over,
pubmed-meshheading:8630519-C-Peptide,
pubmed-meshheading:8630519-Female,
pubmed-meshheading:8630519-Glucose,
pubmed-meshheading:8630519-Glucose Clamp Technique,
pubmed-meshheading:8630519-Humans,
pubmed-meshheading:8630519-Hyperglycemia,
pubmed-meshheading:8630519-Insulin,
pubmed-meshheading:8630519-Male,
pubmed-meshheading:8630519-Middle Aged,
pubmed-meshheading:8630519-Proinsulin
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pubmed:year |
1996
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pubmed:articleTitle |
Proinsulin, C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp.
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pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark.
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pubmed:publicationType |
Journal Article
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