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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-6-27
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pubmed:abstractText |
The CD40-CD40 ligand (CD40L) signaling process is a pivotal component of multiple immunoregulatory pathways. Although the role that CD40L plays in humoral immune responses is fairly well defined, its function(s) in cell-mediated responses in vivo has not been established. We investigated this issue by assessing the course of Leishmania major infection in CD40L knockout (CD40LKO) mice that were generated on a resistant background. In response to parasite challenge, CD40LKO mice developed ulcerating cutaneous lesions and failed to mount a vigorous Th1-like response. The impaired Th1-like response appears to be related to a defect in the ability of CD40LKO T cells to induce the production of IL-12 from macrophages. Treatment with exogenous IL-12 prevented disease progression in CD40LKO mice, and administration of recombinant CD40L provided partial protection against infection. Thus, a protective cell-mediated immune response to L. major appears to be dependent upon CD40L-induced IL-12 secretion by antigen-presenting cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8624818-Animals,
pubmed-meshheading:8624818-Antigens, CD40,
pubmed-meshheading:8624818-CD40 Ligand,
pubmed-meshheading:8624818-Disease Susceptibility,
pubmed-meshheading:8624818-Immunity, Cellular,
pubmed-meshheading:8624818-Interleukin-12,
pubmed-meshheading:8624818-Leishmania major,
pubmed-meshheading:8624818-Leishmaniasis, Cutaneous,
pubmed-meshheading:8624818-Ligands,
pubmed-meshheading:8624818-Macrophages, Peritoneal,
pubmed-meshheading:8624818-Membrane Glycoproteins,
pubmed-meshheading:8624818-Mice,
pubmed-meshheading:8624818-Mice, Inbred BALB C,
pubmed-meshheading:8624818-Mice, Inbred C57BL,
pubmed-meshheading:8624818-Mice, Knockout,
pubmed-meshheading:8624818-Recombinant Proteins,
pubmed-meshheading:8624818-Th1 Cells
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pubmed:year |
1996
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pubmed:articleTitle |
CD40 ligand is required for protective cell-mediated immunity to Leishmania major.
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pubmed:affiliation |
Department of Cellular Immunology, Immunex Corporation, Seattle, Washington 98101, USA.
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pubmed:publicationType |
Journal Article
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