Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
1996-6-10
|
| pubmed:abstractText |
Acute inflammation in the lung is characterized by a phase of tissue injury followed by a phase of tissue repair. When the latter is excessive, fibrosis occurs. Alveolar macrophages (AM) can produce cytokines involved in both phases of acute lung inflammation, notably interleukin-6 (IL-6), involved in injury and transforming growth factor-beta (TGF-beta), mediating repair. We hypothesized that AM were activated in both phases, and studied IL-6 and TGF-beta production by AM during complications of lung transplantation, acute rejection (AR), and cytomegalovirus pneumonitis (CMVP). In addition, we analyzed these cytokines in bronchiolitis obliterans (BO), a fibrotic complication of lung transplantation linked to previous AR and CMVP. At the onset of AR and CMVP, IL-6 secretion increased, whereas AM TGF-beta content was increased, but not its secretion. In contrast, with time, IL-6 reached control value whereas TGF-beta secretion rose significantly. In BO, IL-6 was not oversecreted, but TGF-beta increased, notably before functional abnormalities occurred. These results show that during acute complications of lung transplantation, AM display an early activation with oversecretion of IL-6, which is involved in tissue injury, counterbalanced by a late activation in which TGF-beta predominates, mediating tissue repair. The results provide new insights into the pathogenesis of BO, which is linked to acute complications of lung transplantation through this biphasic AM activation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1073-449X
|
| pubmed:author |
pubmed-author:BadierMM,
pubmed-author:BongrandPP,
pubmed-author:BrisseJJ,
pubmed-author:CapeMM,
pubmed-author:EscallierJ CJC,
pubmed-author:FuentesPP,
pubmed-author:GaranRR,
pubmed-author:GiudicelliRR,
pubmed-author:MagnanAA,
pubmed-author:MegeJ LJL,
pubmed-author:MericBB,
pubmed-author:MetrasDD,
pubmed-author:NoirclercMM,
pubmed-author:ReynaudMM,
pubmed-author:ThomasPP,
pubmed-author:VervloetDD,
pubmed-author:ViaroGG
|
| pubmed:issnType |
Print
|
| pubmed:volume |
153
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1431-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8616577-Adolescent,
pubmed-meshheading:8616577-Adult,
pubmed-meshheading:8616577-Bronchiolitis Obliterans,
pubmed-meshheading:8616577-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:8616577-Child,
pubmed-meshheading:8616577-Cytomegalovirus Infections,
pubmed-meshheading:8616577-Female,
pubmed-meshheading:8616577-Graft Rejection,
pubmed-meshheading:8616577-Humans,
pubmed-meshheading:8616577-Immunohistochemistry,
pubmed-meshheading:8616577-Interleukin-6,
pubmed-meshheading:8616577-Lung,
pubmed-meshheading:8616577-Lung Transplantation,
pubmed-meshheading:8616577-Macrophages, Alveolar,
pubmed-meshheading:8616577-Male,
pubmed-meshheading:8616577-Middle Aged,
pubmed-meshheading:8616577-Pneumonia, Viral,
pubmed-meshheading:8616577-Postoperative Complications,
pubmed-meshheading:8616577-Transforming Growth Factor beta
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Balance between alveolar macrophage IL-6 and TGF-beta in lung-transplant recipients. Marseille and Montréal Lung Transplantation Group.
|
| pubmed:affiliation |
Chest Medicine and Allergy Department, U INSERM 387, St.-Marguerite Hospital, Marseilles, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|