| pubmed-article:8581122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8581122 | lifeskim:mentions | umls-concept:C0697139 | lld:lifeskim |
| pubmed-article:8581122 | lifeskim:mentions | umls-concept:C0064971 | lld:lifeskim |
| pubmed-article:8581122 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:8581122 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:8581122 | lifeskim:mentions | umls-concept:C0008550 | lld:lifeskim |
| pubmed-article:8581122 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8581122 | pubmed:dateCreated | 1996-3-21 | lld:pubmed |
| pubmed-article:8581122 | pubmed:abstractText | Several lignans, mostly new, were isolated from Larrea tridentata by assay-guided counter-current chromatography (CCC). Using the secreted alkaline phosphatase bioassay of HIV Tat transactivation and the two-phase hexane-ethyl acetate-methanol-water solvent system, two major components (Gr and Lo) were identified as anti-HIV active principles. The chemical structures of the constituents of Gr (G1-G4) and Lo (L1-L4) were determined by GC-MS and NMR. After optimization of isolation conditions, a large-scale isolation with the chloroform-methanol-water system yielded five constituents (FB1-FB5). The most predominant anti-HIV compound FB2 (denoted Malachi 4:5-6 or mal.4), which occurs in 0.23% yield, was separated from its FB1 isomer (0.13% yield). Compound FB4 and two tricyclic lignans (FB3 and FB5) were also isolated in a substantial amount for further testing of their anti-HIV activities. These compounds may represent a new class of anti-HIV agents with important clinical relevance. | lld:pubmed |
| pubmed-article:8581122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8581122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8581122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8581122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8581122 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8581122 | pubmed:issn | 0021-9673 | lld:pubmed |
| pubmed-article:8581122 | pubmed:author | pubmed-author:ItoYY | lld:pubmed |
| pubmed-article:8581122 | pubmed:author | pubmed-author:HuangR CRC | lld:pubmed |
| pubmed-article:8581122 | pubmed:author | pubmed-author:LoNN | lld:pubmed |
| pubmed-article:8581122 | pubmed:author | pubmed-author:GnabreJ NJN | lld:pubmed |
| pubmed-article:8581122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8581122 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8581122 | pubmed:volume | 719 | lld:pubmed |
| pubmed-article:8581122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8581122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8581122 | pubmed:pagination | 353-64 | lld:pubmed |
| pubmed-article:8581122 | pubmed:dateRevised | 2009-1-15 | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:meshHeading | pubmed-meshheading:8581122-... | lld:pubmed |
| pubmed-article:8581122 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8581122 | pubmed:articleTitle | Isolation of anti-HIV-1 lignans from Larrea tridentata by counter-current chromatography. | lld:pubmed |
| pubmed-article:8581122 | pubmed:affiliation | Department of Biology, Johns Hopkins University, Baltimore, MD 21218-2685, USA. | lld:pubmed |
| pubmed-article:8581122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8581122 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8581122 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8581122 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8581122 | lld:pubmed |
