Linked Life Data

8580436

Source:http://linkedlifedata.com/resource/pubmed/id/8580436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1996-3-19
pubmed:abstractText
The properties of a transport system specific for L-glutamate and L-aspartate activity expressed in Bergmann glia cells from chick cerebellum were examined. The uptake of D-[3H]aspartate was inhibited by the endogenous substrates L-aspartate (Ki = 62 microM) and L-glutamate (Ki = 60 microM). Of the identified uptake inhibitors, L-aspartate-beta-hydroxamate (Ki = 900 microM), L-alpha-aminoadipate (Ki = 2000 microM), 4,4'diisothiocyanatos-tilbene-2,2'-disulphonic acid (DIDS) (Ki = 1000 microM) and 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulphonic acid (SITS) (Ki = 100 microM) inhibited D-[3H]aspartate uptake. Northern blot analysis, revealed the expression of a chick homologue of a the rat brain L-glutamate/L-aspartate transporter (GLAST). These data suggest that GLAST may be involved in the regulation of the parallel fibre-Purkinje cell synapse ensheathed by Bergmann glia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2041-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Characterization of an Na(+)-dependent glutamate/aspartate transporter from cultured Bergmann glia.
pubmed:affiliation
Departamento de Genética y Biología Molecular, CINVESTAV-IPN, México, DF, México.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't