Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-3-11
pubmed:abstractText
Synovial sarcoma is characterized cytogenetically by translocation t(X;18)(p11.2;q11.2). In this study, 28 cases that had been diagnosed initially as synovial sarcoma, including 2 fibrosarcomas, and 1 leiomyosarcoma were collected and examined for translocation t(X;18) on paraffin-embedded tissues by fluorescence in situ hybridization (FISH). Of the synovial sarcomas, 25 showed findings consistent with translocation t(X;18) with an additional copy signal for the total probe of X and 18 chromosomes. The other three cases, as well as the two fibrosarcomas and the leiomyosarcoma, did not show this translocation. One (case 26) of three negative cases was diagnosed finally as leiomyosarcoma and another (case 27) as malignant peripheral nerve sheath tumor from histological and immunohistochemical analysis. Thus, in all, 25 (96%) of 26 synovial sarcomas showed findings consistent with translocation t(X;18). In summary, translocation t(X;18) is a chromosomal aberration specific for synovial sarcoma. The fluorescence in situ hybridization technique can be used even on cells from paraffin-embedded tissues, and is a useful diagnostic aid for synovial sarcoma.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1350754, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1373322, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1379714, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1648957, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1657367, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1665704, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1985781, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-1988828, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2165233, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2171298, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2176128, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2536862, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2541892, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2755080, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2822225, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2825963, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2838162, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2842027, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2851774, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-2995626, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3030537, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3031659, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3342387, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3458254, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3461881, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-3967551, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-7633662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-7787993, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-7790992, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-7951320, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8160775, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8203453, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8275440, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8311109, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8381297, http://linkedlifedata.com/resource/pubmed/commentcorrection/8579122-8391214
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8579122-Adolescent, pubmed-meshheading:8579122-Adult, pubmed-meshheading:8579122-Aged, pubmed-meshheading:8579122-Aged, 80 and over, pubmed-meshheading:8579122-Child, pubmed-meshheading:8579122-Chromosomes, Human, Pair 18, pubmed-meshheading:8579122-DNA Probes, pubmed-meshheading:8579122-Epithelial Cells, pubmed-meshheading:8579122-Female, pubmed-meshheading:8579122-Humans, pubmed-meshheading:8579122-Immunophenotyping, pubmed-meshheading:8579122-In Situ Hybridization, Fluorescence, pubmed-meshheading:8579122-Male, pubmed-meshheading:8579122-Middle Aged, pubmed-meshheading:8579122-Paraffin Embedding, pubmed-meshheading:8579122-Sarcoma, Synovial, pubmed-meshheading:8579122-Soft Tissue Neoplasms, pubmed-meshheading:8579122-Translocation, Genetic, pubmed-meshheading:8579122-X Chromosome
pubmed:year
1996
pubmed:articleTitle
Chromosomal translocation t(X;18) in human synovial sarcomas analyzed by fluorescence in situ hybridization using paraffin-embedded tissue.
pubmed:affiliation
Department of Pathology, Faculty of Medicine, Tottori University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't