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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-3-14
|
| pubmed:abstractText |
Amylase-resistant starch (RS) represents a substrate for the bacterial flora of the colon, and the question arises as whether RS shares with soluble fibers common mechanisms for their lipid-lowering effects. It is uncertain whether a cholesterol-lowering effect depends basically on an enhanced rate of steroid excretion or whether colonic fermentations also play a role in this effect. In the present study, the effect of RS (25% raw potato starch), of a steroid sequestrant (0.8% cholestyramine), or both were compared on bile acid excretion and lipid metabolism in rats fed semipurified diets. RS diets led to a marked rise in cecal size and the cecal pool of short-chain fatty acids (SCFA), as well as SCFA absorption; cholestyramine did not noticeably affect cecal fermentation. Whereas cholestyramine was particularly effective at enhancing bile acid excretion, RS was more effective in lowering plasma cholesterol (-32%) and triglycerides (-29%). The activity of 3-hydroxy-3-methylglutaryl-CoA reductase was increased fivefold by cholestyramine and twofold by RS. This induction in rats fed RS diets was concomittant to a depressed fatty acid synthase activity. In rats fed the RS diet, there was a lower concentration of cholesterol in all lipoprotein fractions, especially the (d = 1.040-1.080) fraction high-density lipoprotein (HDL1), while those fed cholestyramine had only a significant reduction of HDL1 cholesterol. In contrast to cholestyramine, RS also depressed the concentration of triglycerides in the triglyceride-rich lipoprotein fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amylases,
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bile Acids and Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholestyramine Resin,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl CoA Reductases,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Starch,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0024-4201
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
847-53
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8577229-Amylases,
pubmed-meshheading:8577229-Animals,
pubmed-meshheading:8577229-Anticholesteremic Agents,
pubmed-meshheading:8577229-Bile Acids and Salts,
pubmed-meshheading:8577229-Body Weight,
pubmed-meshheading:8577229-Cecum,
pubmed-meshheading:8577229-Cholesterol,
pubmed-meshheading:8577229-Cholestyramine Resin,
pubmed-meshheading:8577229-Eating,
pubmed-meshheading:8577229-Feces,
pubmed-meshheading:8577229-Fermentation,
pubmed-meshheading:8577229-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:8577229-Intestine, Small,
pubmed-meshheading:8577229-Lipoproteins, HDL,
pubmed-meshheading:8577229-Liver,
pubmed-meshheading:8577229-Male,
pubmed-meshheading:8577229-Organ Size,
pubmed-meshheading:8577229-Rats,
pubmed-meshheading:8577229-Rats, Wistar,
pubmed-meshheading:8577229-Starch,
pubmed-meshheading:8577229-Triglycerides
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Resistant starch is more effective than cholestyramine as a lipid-lowering agent in the rat.
|
| pubmed:affiliation |
Laboratoire des Maladies Métaboliques, INRA de Clermont-Ferrand/Theix, St-Genès-Champanelle, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|