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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0033684,
umls-concept:C0086222,
umls-concept:C0332453,
umls-concept:C0439849,
umls-concept:C0439855,
umls-concept:C0445223,
umls-concept:C0599894,
umls-concept:C1417166,
umls-concept:C1519595,
umls-concept:C1521840,
umls-concept:C1522424,
umls-concept:C1534709,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1705733,
umls-concept:C1880022
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pubmed:issue |
3
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pubmed:dateCreated |
1996-3-12
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pubmed:abstractText |
The Grg gene encodes a 197 amino acid protein homologous to the amino-terminal domain of the product of the groucho gene of the Drosophila Enhancer of split complex. Analysis with a polyclonal antisera specific for the Grg protein revealed that Grg is a 25 kd nuclear protein that can participate in specific protein-protein interactions. A null mutation of the Grg gene was constructed by gene targeting. Mice homozygous for this mutation completed embryogenesis and were born, but exhibited varying degrees of post-natal growth deficiency. No dosage-sensitive genetic interaction was detected between the Notch1 and Grg genes in mice heterozygous for a Notch1 mutant allele and homozygous for the Grg null mutation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aes protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E(spl) region transcript mdelta...,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/groucho protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1058-8388
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
338-47
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8573724-Alleles,
pubmed-meshheading:8573724-Animals,
pubmed-meshheading:8573724-Base Sequence,
pubmed-meshheading:8573724-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:8573724-DNA-Binding Proteins,
pubmed-meshheading:8573724-Drosophila,
pubmed-meshheading:8573724-Drosophila Proteins,
pubmed-meshheading:8573724-Embryonic and Fetal Development,
pubmed-meshheading:8573724-Gene Dosage,
pubmed-meshheading:8573724-Gene Expression Regulation, Developmental,
pubmed-meshheading:8573724-Genes, Lethal,
pubmed-meshheading:8573724-Germ-Line Mutation,
pubmed-meshheading:8573724-Homozygote,
pubmed-meshheading:8573724-Insect Hormones,
pubmed-meshheading:8573724-Mice,
pubmed-meshheading:8573724-Mice, Mutant Strains,
pubmed-meshheading:8573724-Molecular Sequence Data,
pubmed-meshheading:8573724-Protein Binding,
pubmed-meshheading:8573724-Proteins,
pubmed-meshheading:8573724-RNA, Messenger,
pubmed-meshheading:8573724-Repressor Proteins,
pubmed-meshheading:8573724-Transcription, Genetic,
pubmed-meshheading:8573724-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.
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pubmed:affiliation |
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey, USA.
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pubmed:publicationType |
Journal Article
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