Linked Life Data

8571694

Source:http://linkedlifedata.com/resource/pubmed/id/8571694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-3-7
pubmed:abstractText
Neuronal transplantation of dopaminergic embryonic ventral mesencephalic cells aims at replacing the lost striatal dopamine in Parkinson's disease. Functional effects of intrastriatal ventral mesencephalic transplants are reflected in improvements of bradykinesia and rigidity. However, a more widespread clinical application critically depends on further technical refinements, specifically in the area of improved survival of the grafted ventral mesencephalic dopamine neurones. This review highlights some of the progress made in the field of ventral mesencephalic transplantation in animal models of Parkinson's disease and also discusses issues and results obtained by our own research group in Munich. Thus we studied whether cryo- or neuroprotective additives during cryopreservation of ventral mesencephalic tissue can improve survival of such tissue/cells following transplantation. Concerning immunological aspects we studied the effects of pooled or co-transplanted embryonic tissue on survival and function of grafts and whether immunosuppression with cyclosporine A has beneficial effects. Possible neurotoxic effects of cyclosporine A were considered in a separate study. Finally, we established in vivo voltammetry to measure dopamine release from the graft and effects of the grafts on related parts of the dopaminergic system in the living animal. In the clinic we employed guidelines for preoperative patient evaluation and respective tests are described.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-4251
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Neuronal transplantation in animal models of Parkinson disease: in vivo voltammetry, tissue cryopreservation and immunology].
pubmed:affiliation
Neurologische Klinik und Poliklinik Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
pubmed:publicationType
Journal Article, English Abstract, Review