| pubmed-article:8560193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8560193 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8560193 | lifeskim:mentions | umls-concept:C0242245 | lld:lifeskim |
| pubmed-article:8560193 | lifeskim:mentions | umls-concept:C1155008 | lld:lifeskim |
| pubmed-article:8560193 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:8560193 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8560193 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8560193 | pubmed:dateCreated | 1996-2-28 | lld:pubmed |
| pubmed-article:8560193 | pubmed:abstractText | Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of FDC on B-lymphocyte proliferation, we isolated them from human tonsils on albumin gradients and treated them with mitomycin C to prevent the multiplication of lymphoid cells harboured in their cytoplasmic evaginations. FDC cultured for 12-16 h remained attached to the substrate; non-adherent cells were carefully eliminated by washing. Purified B cells cultured alone or with contaminant-cleared FDC were maintained for 2 days in the presence or absence of various stimulants, after which tritiated thymidine uptake by these cells was measured. In the absence of activators, FDC did not induce B-cell multiplication. B cells cultured in the presence of FDC exhibited increased 3H-TdR uptake when activated with anti-CD40 MoAb, anti-immunoglobulin MoAb or transferrin, but not when stimulated with Staphylococcus aureus strain Cowan I (SAC) at a given concentration. In the latter case, B-cell proliferation clearly decreased. In control cocultures where mitomycin-C-treated non-adherent cells were used instead of FDC in the presence of the different stimulants, no increase in B-cell proliferation was observed. The results suggest that, inside the germinal centres, FDC modulation of B-cell proliferation depends on the activation state of the B cells and on the stimulant encountered. | lld:pubmed |
| pubmed-article:8560193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8560193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8560193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8560193 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8560193 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:8560193 | pubmed:author | pubmed-author:HeinenEE | lld:pubmed |
| pubmed-article:8560193 | pubmed:author | pubmed-author:SimarL JLJ | lld:pubmed |
| pubmed-article:8560193 | pubmed:author | pubmed-author:BosseloirAA | lld:pubmed |
| pubmed-article:8560193 | pubmed:author | pubmed-author:BouzahzahFF | lld:pubmed |
| pubmed-article:8560193 | pubmed:author | pubmed-author:DefranceT HTH | lld:pubmed |
| pubmed-article:8560193 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8560193 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:8560193 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8560193 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8560193 | pubmed:pagination | 23-30 | lld:pubmed |
| pubmed-article:8560193 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:meshHeading | pubmed-meshheading:8560193-... | lld:pubmed |
| pubmed-article:8560193 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8560193 | pubmed:articleTitle | The influence of follicular dendritic cells on B-cell proliferation depends on the activation of B cells and the mitogen used. | lld:pubmed |
| pubmed-article:8560193 | pubmed:affiliation | Institute of Human Histology, University of Liège, Belgium. | lld:pubmed |
| pubmed-article:8560193 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8560193 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8560193 | lld:pubmed |
