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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-2-28
|
| pubmed:abstractText |
Preruminant calves are regarded as a model for studying beta-carotene bioavailability in humans. The objectives of this trial were to determine the relationship between multiple beta-carotene doses and plasma steady-state concentration, accumulation in selected tissues, and vitamin A balance in liver. Seventy newborn Holstein calves in six treatments (n = 10/treatment) were fed a complete milk replacer diet low in vitamin A and supplemented with beta-carotene doses of 0, 0.23, 0.46, 0.92, 1.84 or 3.68 mumol/(kg body wt.d) for 28 d. Ten calves were killed on d 1. Plasma beta-carotene increased in relation to log transformations of dose and time (P < 0.05) in all supplemented calves and steady state was attained after 4 wk. For doses up to 0.92 mumol/(kg body wt.d), the dose-response relationship was linear. A dose-dependent accumulation of beta-carotene was found for liver, heart, lungs, adrenals and adipose tissue. All-trans-beta-carotene was the only isomer in plasma and adrenals and the predominant isomer in the remaining tissues. In liver, vitamin A increased with beta-carotene uptake. Hepatic balance between vitamin A accumulation and loss was achieved at beta-carotene intake of 0.36 mumol/(kg body wt.d) for a calf of 45 kg. It is concluded that preruminant calves within 1 mo of age utilize beta-carotene as a source of vitamin A, and that for testing bioavailability of beta-carotene sources, doses up to 0.92 mumol beta-carotene/(kg body wt.d) are most appropriate.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0022-3166
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
126
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
202-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8558302-Adipose Tissue,
pubmed-meshheading:8558302-Aging,
pubmed-meshheading:8558302-Animals,
pubmed-meshheading:8558302-Animals, Newborn,
pubmed-meshheading:8558302-Biological Availability,
pubmed-meshheading:8558302-Carotenoids,
pubmed-meshheading:8558302-Cattle,
pubmed-meshheading:8558302-Diet,
pubmed-meshheading:8558302-Dose-Response Relationship, Drug,
pubmed-meshheading:8558302-Liver,
pubmed-meshheading:8558302-Male,
pubmed-meshheading:8558302-Myocardium,
pubmed-meshheading:8558302-Time Factors,
pubmed-meshheading:8558302-Vitamin A,
pubmed-meshheading:8558302-beta Carotene
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Dietary beta-carotene elevates plasma steady-state and tissue concentrations of beta-carotene and enhances vitamin A balance in preruminant calves.
|
| pubmed:affiliation |
Animal Nutrition Research Station, BASF Aktiengesellschaft, Offenbach, Germany.
|
| pubmed:publicationType |
Journal Article
|