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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-6-18
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pubmed:abstractText |
A retrospective analysis was performed of 18 patients with primary malignant germ cell tumours of the mediastinum treated with platinum-based chemotherapy between 1977 and 1990. All seven patients with pure seminoma were treated initially with chemotherapy and four of these patients received additional mediastinal radiotherapy. Only one patient relapsed; his initial therapy had included radiotherapy and single-agent carboplatin and he was successfully salvaged with combination chemotherapy. With a follow-up of 11 to 117 months (median 41 months) all seven patients with seminoma remain alive and disease free giving an overall survival of 100%. Eleven patients had malignant non seminoma; following chemotherapy eight of these had elective surgical resection of residual mediastinal masses. Complete remission was achieved in nine (82%) patients, however, one of these patients died from bleomycin pneumonitis. With a follow-up of 12 to 113 months (median 55 months) eight of 11 (73%) patients with malignant mediastinal teratoma remain alive and disease free.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-1237349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-1309383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-14136533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-1690077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-1848473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-1851024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2158625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2410574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2446572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2449276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2457402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2467806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2550400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2579212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2666591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2681557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-2778480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-3039830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-6155194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-6189504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-71004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8494705-7226117
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1098-101
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8494705-Adult,
pubmed-meshheading:8494705-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:8494705-Carboplatin,
pubmed-meshheading:8494705-Cisplatin,
pubmed-meshheading:8494705-Dysgerminoma,
pubmed-meshheading:8494705-Humans,
pubmed-meshheading:8494705-Male,
pubmed-meshheading:8494705-Mediastinal Neoplasms,
pubmed-meshheading:8494705-Prognosis,
pubmed-meshheading:8494705-Retrospective Studies,
pubmed-meshheading:8494705-Teratoma
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pubmed:year |
1993
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pubmed:articleTitle |
Primary malignant mediastinal germ cell tumours: improved prognosis with platinum-based chemotherapy and surgery.
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pubmed:affiliation |
Oncology Centre, Auckland Hospital, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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