Linked Life Data

8484556

Source:http://linkedlifedata.com/resource/pubmed/id/8484556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-6-3
pubmed:abstractText
The effect of fentanyl, sufentanil, and alfentanil on cerebral arterioles was determined in 17 halothane-anesthetized newborn piglets. A closed cranial window was inserted over the parietal cortex, and changes in the luminal diameter of pial arterioles were measured by intravital microscopy as increasing concentrations of opioid (10(-9)-10(-5) M) were suffused over the cortical surface. Each opioid caused a dose-dependent decrease in arteriolar diameter that was attenuated by coadministration of naloxone (10(-5) M). Fentanyl was more potent than either alfentanil or sufentanil. Naloxone alone had no effect at concentrations < or = 10(-5) M, suggesting that endogenous opioids contribute little to resting cerebrovascular tone. These results indicate that fentanyl, sufentanil, and alfentanil produce cerebral vasoconstriction by action at an opioid receptor and that their vasoconstrictive potency appears to differ from their analgesic potency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
985-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The effect of fentanyl, sufentanil, and alfentanil on cerebral arterioles in piglets.
pubmed:affiliation
Department of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, PA 19104.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't