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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-4-19
|
| pubmed:abstractText |
The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1043-6618
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
53-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8456058-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:8456058-Cell Differentiation,
pubmed-meshheading:8456058-Dimethyl Sulfoxide,
pubmed-meshheading:8456058-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8456058-Humans,
pubmed-meshheading:8456058-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:8456058-Neutrophils,
pubmed-meshheading:8456058-RNA, Messenger,
pubmed-meshheading:8456058-Tumor Cells, Cultured
|
| pubmed:articleTitle |
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO.
|
| pubmed:affiliation |
Institute of Pharmacological Sciences, University of Milan, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|