Linked Life Data

8455761

Source:http://linkedlifedata.com/resource/pubmed/id/8455761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-4-20
pubmed:abstractText
We studied the relationship between tissue polyamine levels and malignancy in 146 primary brain tumors. Astrocytoma showed a consistent rise in levels of N1-acetylspermidine (N1-AcSpd) in tissue with increased grade of malignancy. Furthermore, in astrocytoma, the patients whose tumors contained high levels of N1-AcSpd (> or = 15 nmol/g) in tissue showed a far worse prognosis, a significantly lower recurrence-free survival rate, and a shorter survival rate than did the patients whose tumors contained lower levels of N1-AcSpd (< 15 nmol/g). High-grade astrocytoma contained N1-AcSpd at the level of 15 nmol/g or higher, and most of the benign brain tumors, including low-grade astrocytoma, meningioma, pituitary adenoma, and normal brain tissues contained much lower levels of N1-AcSpd. However, medulloblastoma, hemangiopericytoma, and neurinoma showed an inverse correlation between N1-AcSpd levels in tissue and biological malignancy. These results suggest that levels of N1-AcSpd in tissue can be a promising biochemical marker of malignancy in astrocytoma. In the other primary brain tumors, however, the relationship between levels of N1-AcSpd in tissue and biological malignancy should be examined in each histopathological type.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0148-396X
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
372-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Relationship between tissue polyamine levels and malignancy in primary brain tumors.
pubmed:affiliation
Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
pubmed:publicationType
Journal Article