Linked Life Data

8448410

Source:http://linkedlifedata.com/resource/pubmed/id/8448410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-15
pubmed:abstractText
In nonhuman vertebrate embryos, two endogenous retinoids with significant morphogenic activities have been identified thus far: all-trans retinoic acid and 3, 4-didehydroretinoic acid. To date, no information is available concerning endogenous retinoid levels in developing human embryos or fetuses. The purpose of the present study was to provide data relating to normal levels of retinoids in various human embryonic and fetal tissues at various stages of gestation measurable with HPLC techniques. Our investigations show that all-trans-retinoic acid, 13-cis-retinoic acid, retinol, all-trans-retinoyl-beta-glucuronide, and one unidentified metabolite were all present and quantifiable in several human embryos and fetuses investigated. Tissue levels of retinol were consistently much higher than those of the other three detected metabolites; 4-oxo metabolites were below the levels of detection in all samples studied.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0890-6238
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Tissue levels of retinoids in human embryos/fetuses.
pubmed:affiliation
Department of Pharmacology, University of Washington, School of Medicine, Seattle 98195.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.