Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-3-26
pubmed:abstractText
The protein-tyrosine kinases Trk, TrkB, and TrkC are signal-transducing receptors for a family of neurotrophic factors known as the neurotrophins. Here we show that seizures induced by hippocampal kindling lead to a rapid, transient increase of trkB mRNA and protein in the hippocampus. TrkB is a component of a high affinity receptor for brain-derived neurotrophic factor (BDNF). No change was detected in mRNAs for Trk or TrkC, components of the high affinity nerve growth factor or neurotrophin-3 receptors, respectively. trkB mRNA was also transiently increased in the dentate gyrus following cerebral ischemia and hypoglycemic coma; these treatments had no effect on trk and trkC mRNAs. The increase in trkB mRNA and protein showed the same time course and distribution as the increase in BDNF mRNA. These data suggest that BDNF and its receptor may play a local role within the hippocampus in kindling-associated neural plasticity and in neuronal protection following epileptic, ischemic, and hypoglycemic insults.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
151-64
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8439408-Animals, pubmed-meshheading:8439408-Base Sequence, pubmed-meshheading:8439408-Brain Diseases, pubmed-meshheading:8439408-Brain Ischemia, pubmed-meshheading:8439408-Brain-Derived Neurotrophic Factor, pubmed-meshheading:8439408-Coma, pubmed-meshheading:8439408-Gene Expression, pubmed-meshheading:8439408-Hippocampus, pubmed-meshheading:8439408-Humans, pubmed-meshheading:8439408-Hypoglycemia, pubmed-meshheading:8439408-Kindling, Neurologic, pubmed-meshheading:8439408-Male, pubmed-meshheading:8439408-Membrane Glycoproteins, pubmed-meshheading:8439408-Membrane Proteins, pubmed-meshheading:8439408-Molecular Sequence Data, pubmed-meshheading:8439408-Nerve Tissue Proteins, pubmed-meshheading:8439408-Protein-Tyrosine Kinases, pubmed-meshheading:8439408-RNA, Messenger, pubmed-meshheading:8439408-Rats, pubmed-meshheading:8439408-Rats, Sprague-Dawley, pubmed-meshheading:8439408-Rats, Wistar, pubmed-meshheading:8439408-Receptor, Ciliary Neurotrophic Factor, pubmed-meshheading:8439408-Receptor, trkC, pubmed-meshheading:8439408-Receptors, Nerve Growth Factor, pubmed-meshheading:8439408-Seizures
pubmed:year
1993
pubmed:articleTitle
Increased production of the TrkB protein tyrosine kinase receptor after brain insults.
pubmed:affiliation
Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't