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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-1-25
|
| pubmed:abstractText |
The effect of cortical spreading depression (CSD) on cerebral protein synthesis (CPS) was examined. CSD was evoked in normal rats with KCl, and CPS was measured autoradiographically with [1-14C]leucine. Average rates (mean +/- SD) of CPS in layers I-IV of cortex decreased significantly from 10.7 +/- 0.6 (sham-operated controls; n = 4) to 6.7 +/- 0.7 nmol/g/min (n = 4; p < 0.01) and in layers V-VI from 10.9 +/- 0.5 to 9.4 +/- 0.4 nmol/g/min (p < 0.05) during 60 min of repetitive CSD. Spreading depression did not affect CPS rates in other subcortical brain regions. These results indicate that KCl-evoked CSD induces inhibition but not suppression of cortical protein synthesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-3042
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
360-3
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8417158-Animals,
pubmed-meshheading:8417158-Autoradiography,
pubmed-meshheading:8417158-Cerebral Cortex,
pubmed-meshheading:8417158-Cortical Spreading Depression,
pubmed-meshheading:8417158-Electroencephalography,
pubmed-meshheading:8417158-Female,
pubmed-meshheading:8417158-Potassium Chloride,
pubmed-meshheading:8417158-Protein Biosynthesis,
pubmed-meshheading:8417158-Proteins,
pubmed-meshheading:8417158-Rats,
pubmed-meshheading:8417158-Rats, Inbred F344
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Inhibition of protein synthesis during repetitive cortical spreading depression.
|
| pubmed:affiliation |
Department of Experimental Neurology, Max-Planck-Institute for Neurological Research, Cologne, F.R.G.
|
| pubmed:publicationType |
Journal Article
|