Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
1993-11-9
pubmed:abstractText
Mouse biliary glycoprotein (Bgp) is a member of the carcinoembryonic antigen gene family and is highly expressed in the epithelial cells of normal hepatic biliary ducts and intestine. Nine mouse Bgp isoforms have been identified through molecular cloning and shown to be splice and allelic variants of one Bgp gene. These glycoproteins function in vitro as intercellular adhesion molecules and serve as the mouse hepatitis virus receptors. Since human carcinoembryonic antigen is overexpressed in gastrointestinal tumors, we have investigated the expression of mouse Bgp in primary tumors and carcinoma cell lines. Our results demonstrate that the expression of the major mouse Bgp isoforms is down-regulated in tumors at the transcriptional and the posttranscriptional levels. This decrease in expression is corroborated by immunostaining of primary colonic tumors with anti-mouse Bgp antibodies. In addition, Bgp expression is influenced by transcriptional control mechanisms involving DNA methylation of the Bgp gene upstream regulatory region. Our results demonstrate that mouse Bgp protein expression is decreased upon malignant transformation and further suggest that Bgp proteins may be involved in the maintenance of the differentiated cellular phenotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
53
pubmed:geneSymbol
BGP, CEA
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4938-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8402684-3T3 Cells, pubmed-meshheading:8402684-Animals, pubmed-meshheading:8402684-Antibodies, pubmed-meshheading:8402684-Blotting, Northern, pubmed-meshheading:8402684-Blotting, Southern, pubmed-meshheading:8402684-Carcinoembryonic Antigen, pubmed-meshheading:8402684-Cell Line, pubmed-meshheading:8402684-Colonic Neoplasms, pubmed-meshheading:8402684-Female, pubmed-meshheading:8402684-Gene Expression Regulation, Neoplastic, pubmed-meshheading:8402684-Glycoproteins, pubmed-meshheading:8402684-Immunoblotting, pubmed-meshheading:8402684-Mammary Neoplasms, Experimental, pubmed-meshheading:8402684-Mice, pubmed-meshheading:8402684-Mice, Inbred BALB C, pubmed-meshheading:8402684-Mice, Inbred C3H, pubmed-meshheading:8402684-Mice, Inbred C57BL, pubmed-meshheading:8402684-Mice, Inbred Strains, pubmed-meshheading:8402684-Neoplasms, Experimental, pubmed-meshheading:8402684-RNA, Messenger, pubmed-meshheading:8402684-Rectal Neoplasms, pubmed-meshheading:8402684-Transfection, pubmed-meshheading:8402684-Tumor Cells, Cultured
pubmed:year
1993
pubmed:articleTitle
The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues.
pubmed:affiliation
McGill Cancer Center, McGill University, Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't