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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1993-10-12
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pubmed:abstractText |
Sendai virus pneumonia in beta 2-microglobulin-deficient [beta 2-m(-/-)] mice lacking CD8+ T cells is characterized by the development of CD4+ cytotoxic T lymphocytes that can be recovered directly from the respiratory tract. These CD4+ cytotoxic T lymphocytes are not found in beta 2-m (+/+) mice, though inflammatory CD4+ T cells from both beta 2-m (-/-) and beta 2-m (+/+) mice produce substantial amounts of tumor necrosis factor alpha. Blocking experiments with a monoclonal antibody that also inhibits tumor necrosis factor beta show that the secreted forms of these two cytokines are not responsible for virus-specific killing of class II major histocompatibility complex-compatible targets. Comparison of electron micrographs indicates that the CD4+ effectors from the beta 2-m (-/-) mice are potent inducers of apoptosis, while this is not the case for the beta 2-m (+/+) CD4+ set. These experiments further define the functional status of virus-specific CD4+ T cells responding in vivo in the presence or absence of CD8+ effectors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1347959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1351088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1354233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1354650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1530795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1552285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1552287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1590988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1590993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1591000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1631092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1692070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1832087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-1919440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-2139497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-2212948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-2273386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-2469726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-3024126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-3491143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-7688517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-7916655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-8093219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8396684-8416386
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6299-302
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8396684-Animals,
pubmed-meshheading:8396684-Antigens, CD4,
pubmed-meshheading:8396684-Cell Adhesion,
pubmed-meshheading:8396684-Cells, Cultured,
pubmed-meshheading:8396684-Cytotoxicity, Immunologic,
pubmed-meshheading:8396684-Histocompatibility Antigens Class I,
pubmed-meshheading:8396684-Inflammation,
pubmed-meshheading:8396684-Mice,
pubmed-meshheading:8396684-Microscopy, Electron,
pubmed-meshheading:8396684-Parainfluenza Virus 1, Human,
pubmed-meshheading:8396684-Paramyxoviridae Infections,
pubmed-meshheading:8396684-Pneumonia, Viral,
pubmed-meshheading:8396684-T-Lymphocyte Subsets,
pubmed-meshheading:8396684-Tumor Necrosis Factor-alpha
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pubmed:year |
1993
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pubmed:articleTitle |
Divergence between cytotoxic effector function and tumor necrosis factor alpha production for inflammatory CD4+ T cells from mice with Sendai virus pneumonia.
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pubmed:affiliation |
Department of Immunology, St. Judge Children's Research Hospital, Memphis, Tennessee 38105.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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