Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-5-17
pubmed:abstractText
Poliovirus mutants selected in persistently infected human neuroblastoma cells have a modified cell tropism and can establish a secondary persistent infection in nonneural cells, such as HEp-2c cells. Nucleotide sequence analysis revealed that the genome of a persistent mutant, S11, differed from that of the parental lytic Sabin 1 poliovirus strain by 31 point mutations. Three mutations occurred in the noncoding regions. The other mutations resulted in 12 amino acid substitutions; 1 substitution occurred in a nonstructural protein (3A), while the other 11 substitutions were clustered in the capsid proteins VP2 and VP1. The same missense mutations, as well as many of the silent mutations that we observed in mutant S11, also accumulated in the genome of two other persistent viruses isolated from independent infections. This finding indicates that both missense and silent mutations are selected during the persistent infection of neuroblastoma cells and suggests that the secondary structure of RNA in the coding region may play a role in viral infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1309611, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1310176, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1313561, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1316481, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1372037, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1651456, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1661980, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1705992, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1840619, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1846495, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1850038, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1850692, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1923765, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-195206, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-1957717, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2072451, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2152812, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2157861, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2168976, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2170684, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-226978, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2460345, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2539524, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2544735, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2547075, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2550319, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2552448, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-2838906, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-3008430, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-3033275, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-3780783, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-3912262, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-5388078, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-6202874, http://linkedlifedata.com/resource/pubmed/commentcorrection/8386281-6266333
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2914-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Precise missense and silent point mutations are fixed in the genomes of poliovirus mutants from persistently infected cells.
pubmed:affiliation
Unité de Virologie Médicale, Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't