Linked Life Data

8373392

Source:http://linkedlifedata.com/resource/pubmed/id/8373392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-10-12
pubmed:abstractText
Endochondral bone development can be induced by subcutaneous implantation of demineralized bone matrix (DBM) in rats. We used this in vivo model to study the relationship between endochondral bone formation and expression of IGF-II/M-6-P receptor, a multifunctional protein which binds not only IGF-II, but also lysosomal enzyme bearing mannose-6-phosphate motif. We found that IGF-II/M-6-P receptor was present in implants from day 1 to day 21; the highest levels were expressed on day 11 during bone differentiation. IGF-II/M-6-P receptor mRNA content was highest on day 9. We conclude from these data that IGF-II/M-6-P receptor expression is developmentally regulated during endochondral bone formation. This regulation occurs in part at the level of IGF-II/M-6-P receptor mRNA. The relatively high level of IGF-II/M-6-P receptor during ossification suggests that this receptor might play a role in bone formation and remodeling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
195
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
516-24
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Changes in the expression of insulin-like growth factor II/mannose-6-phosphate receptor during endochondral bone development.
pubmed:affiliation
Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
pubmed:publicationType
Journal Article