Linked Life Data

8297377

Source:http://linkedlifedata.com/resource/pubmed/id/8297377

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-3-1
pubmed:abstractText
Casein kinase II is a ubiquitous serine-threonine kinase made of two different (alpha and beta) subunits, with an alpha 2 beta 2 stoichiometry, alpha bearing the catalytic site of the enzyme. Two different genes encode two different (alpha and alpha') catalytic subunits. The present work shows that at least two forms of CKII (CKIIa and CKIIb) can be isolated from bovine tissues and adrenocortical cells in culture. The use of specific antibodies developed against the alpha and alpha' subunits disclosed that while CKIIa contains both alpha and alpha', the alpha subunit was highly prominent in CKIIb. This suggests that CKIIb may be an alpha 2 beta 2 oligomer whereas CKIIa may be an alpha alpha' beta 2 moiety or an alpha alpha' beta 2 and alpha' 2 beta 2 mixture. Transition from quiescence to proliferation was concomitant with an average two fold increase in total cell CKII activity involving both CKIIa and CKIIb isoforms. The two isoforms were found in cytosolic and particulate adrenocortical subcellular preparations and they similarly increased their association to intracellular organelles in response to growth stimulatory conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
660-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Oligomeric casein kinase II isoforms are expressed in bovine tissues and adrenocortical cells in culture.
pubmed:affiliation
CEA, Laboratoire de Biochimie des Régulations Cellulaires Endocrines, INSERM Unité 244, DBMS, CEN-Grenoble, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't