Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-3-2
pubmed:abstractText
Eleven pairs of surgically resected lung cancers and corresponding non-neoplastic lung tissue were evaluated for metallothionein (MT) and metal content (cadmium and copper) by the heme/109Cd binding assay and atomic absorption spectroscopy, respectively. Tissue samples, obtained from patients ranging in age from 51 to 79, included six adenocarcinomas, two small cell carcinomas, one mixed cell carcinoma, one squamous cell carcinoma, and one carcinoma of non-primary origin (i.e., melanoma). Paired t-tests showed that metallothionein and copper concentrations in lung tumor tissue were significantly elevated when compared to non-malignant lung tissue. Cu was the major metal associated with the 10 kDa MT fraction in lung tumors whereas Cd was the primary metal bound to MT from non-neoplastic lung tissue. Since Cu-thionein is also known to be elevated in fetal lung tissue, the possibility exists that MT might represent an oncodevelopmental product which is useful as a biomarker for the early detection of lung carcinoma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8293422-Adenocarcinoma, pubmed-meshheading:8293422-Aged, pubmed-meshheading:8293422-Cadmium, pubmed-meshheading:8293422-Cadmium Radioisotopes, pubmed-meshheading:8293422-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:8293422-Carcinoma, Squamous Cell, pubmed-meshheading:8293422-Cell Transformation, Neoplastic, pubmed-meshheading:8293422-Chromatography, Agarose, pubmed-meshheading:8293422-Copper, pubmed-meshheading:8293422-Humans, pubmed-meshheading:8293422-Lung, pubmed-meshheading:8293422-Lung Neoplasms, pubmed-meshheading:8293422-Melanoma, pubmed-meshheading:8293422-Metallothionein, pubmed-meshheading:8293422-Middle Aged, pubmed-meshheading:8293422-Neoplasm Proteins, pubmed-meshheading:8293422-Protein Binding, pubmed-meshheading:8293422-Spectrophotometry, Atomic, pubmed-meshheading:8293422-Tumor Markers, Biological
pubmed:year
1993
pubmed:articleTitle
Metallothionein in human lung carcinoma.
pubmed:affiliation
Department of Biochemistry, University of Vermont College of Medicine, Burlington 05405.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't