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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-17
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pubmed:abstractText |
We dissected and perfused outer medullary vasa recta (OMVR) from vascular bundles in the rat. Permeabilities of sodium (PNa) and urea (Pu) were simultaneously determined from the lumen-to-bath efflux of 22Na and [14C]urea. PNa and Pu were also measured by in vivo microperfusion of descending (DVR) and ascending vasa recta (AVR) at the papillary tip of Munich-Wistar rats. In some OMVR PNa was indistinguishable from zero. The mean +/- SE of PNa (x 10(-5), cm/s) in OMVR was 76 +/- 9. Pu in OMVR was always very high (x 10(-5), cm/s), 360 +/- 14. There was no correlation between OMVR PNa and Pu. Inner medullary AVR and DVR had PNa of 115 +/- 10 and 75 +/- 10, respectively, and Pu of 121 +/- 10 and 76 +/- 11, respectively. PNa and Pu in papillary vasa recta were always nearly identical and highly correlated. Transport of [14C] urea in OMVR was reversibly inhibited by addition of unlabeled urea or phloretin to the bath and lumen, providing evidence for carrier-mediated transport. These data suggest that sodium and urea might traverse the wall of inner medullary vasa recta by a paracellular pathway while urea also crosses by a transcellular route in OMVR. Electron microscopic examination of seven in vitro perfused OMVR revealed no fenestrations and exposure of these vessels to 10 microM calcium ionophore A23187 or 1 nM angiotensin II resulted in reversible contraction, suggesting that in vitro perfused OMVR are DVR only.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-13520770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-1415570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-1699435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-1887911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-1985089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-1996677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-2000954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-2194225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-2506765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-2801959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3110736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3348411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3550222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3550226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3793921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-3826384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4198196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-420405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4629410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4657922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4671532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4685086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-4691283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-5570338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-5659320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-5923067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6287850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6411854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6522245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6522246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6869802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-6883657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-7195562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-7446733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-8413669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-842667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-8447443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8282790-957604
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8282790-Angiotensin II,
pubmed-meshheading:8282790-Animals,
pubmed-meshheading:8282790-Arterioles,
pubmed-meshheading:8282790-Calcimycin,
pubmed-meshheading:8282790-Endothelium, Vascular,
pubmed-meshheading:8282790-Gap Junctions,
pubmed-meshheading:8282790-Kidney Medulla,
pubmed-meshheading:8282790-Kinetics,
pubmed-meshheading:8282790-Membrane Potentials,
pubmed-meshheading:8282790-Microcirculation,
pubmed-meshheading:8282790-Microscopy, Electron,
pubmed-meshheading:8282790-Muscle, Smooth, Vascular,
pubmed-meshheading:8282790-Nephrons,
pubmed-meshheading:8282790-Permeability,
pubmed-meshheading:8282790-Rats,
pubmed-meshheading:8282790-Rats, Sprague-Dawley,
pubmed-meshheading:8282790-Sodium,
pubmed-meshheading:8282790-Urea,
pubmed-meshheading:8282790-Vasoconstriction
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pubmed:year |
1994
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pubmed:articleTitle |
Transport of sodium and urea in outer medullary descending vasa recta.
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pubmed:affiliation |
Division of Nephrology, M.S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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