Linked Life Data

8269096

Source:http://linkedlifedata.com/resource/pubmed/id/8269096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-1-28
pubmed:abstractText
The vitelline membrane of Drosophila eggs is composed of a family of proteins which are cross linked into an insoluble matrix with an overlying waxy layer that prevents desiccation. We present here three sets of experiments which show that integrity of the vitelline membrane requires the activity of the alpha methyl dopa hypersensitive (I(2)amdH or amd) gene in both egg chambers and follicle cells. We show that loss of amd activity either by dietary administration of inhibitors or in genetic mosaics of either the germ line or follicle cells leads to production of defective vitelline membranes and by in situ hybridization, that amd is expressed in both nurse cells and follicle cells. The amd gene product is the first non-structural protein gene described whose activity is required for vitelline membrane biosynthesis. Given its unique role in insects and its demonstrated sensitivity to dietary inhibitors, the amd gene product poses an attractive target for insect control.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0962-1075
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:geneSymbol
Ddc
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-87
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Vitelline membrane biogenesis in Drosophila requires the activity of the alpha-methyl dopa hypersensitive gene (I(2)amd) in both the germline and follicle cells.
pubmed:affiliation
Developmental Biology Center, University of California, Irvine 92717.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.