|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-6-28
|
|
pubmed:abstractText |
Tirapazamine (SR 4233) is a benzotriazine di-N-oxide which acts as a hypoxic cytotoxic agent and as a radiation enhancer when given shortly before or after radiation. Three Phase I clinical trials were designed to determine the maximum tolerated dose, toxicities, pharmacokinetics, and effects on irradiated tumors and normal tissues.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0360-3016
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
29
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
379-82
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8195037-Adult,
pubmed-meshheading:8195037-Aged,
pubmed-meshheading:8195037-Aged, 80 and over,
pubmed-meshheading:8195037-Antineoplastic Agents,
pubmed-meshheading:8195037-Female,
pubmed-meshheading:8195037-Humans,
pubmed-meshheading:8195037-Male,
pubmed-meshheading:8195037-Middle Aged,
pubmed-meshheading:8195037-Muscle Cramp,
pubmed-meshheading:8195037-Neoplasms,
pubmed-meshheading:8195037-Radiation-Sensitizing Agents,
pubmed-meshheading:8195037-Triazines
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Muscle cramping in phase I clinical trials of tirapazamine (SR 4233) with and without radiation.
|
|
pubmed:affiliation |
Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|
