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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-6-14
|
| pubmed:abstractText |
Previously, we demonstrated an enhancement of in vitro antibody (Ab) production in response to T-dependent antigens (TD-Ag) by astaxanthin, a carotenoid without vitamin A activity. The effects of beta-carotene, a carotenoid with vitamin A activity, and lutein, another carotenoid without vitamin A activity, on in vitro Ab production were examined with spleen cells from young and old B6 mice. In addition, the in vivo effects of lutein, astaxanthin, and beta-carotene on Ab production were studied in young and old B6 mice. Lutein, but not beta-carotene, enhanced in vitro Ab production in response to TD-Ags. The depletion of T-helper cells prevented the enhancement of Ab production by lutein and astaxanthin. In vivo Ab production in response to TD-Ag was significantly enhanced by lutein, astaxanthin, and beta-carotene. The numbers of immunoglobulin M- and G-secreting cells also increased in vivo with the administration of these carotenoids when mice were primed with TD-Ags. Antibody production in response to TD-Ags in vivo and in vitro was significantly lower in old than in young B6 mice. Astaxanthin supplements partially restored decreased in vivo Ab production in response to TD-Ags in old B6 mice. Lutein and beta-carotene also enhanced in vivo Ab production in response to TD-Ags in old B6 mice, although to a lesser extent than did astaxanthin. However, none of the carotenoids had an effect on in vivo or in vitro Ab production in response to T-independent antigen. These results indicate significant immunomodulating actions of carotenoids for humoral immune responses to TD-Ags and suggest that carotenoid supplementation may be beneficial in restoring humoral immune responses in older animals.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, T-Independent,
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthophylls,
http://linkedlifedata.com/resource/pubmed/chemical/astaxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0163-5581
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
47-58
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8183722-Adjuvants, Immunologic,
pubmed-meshheading:8183722-Age Factors,
pubmed-meshheading:8183722-Animals,
pubmed-meshheading:8183722-Antibody Formation,
pubmed-meshheading:8183722-Antigens,
pubmed-meshheading:8183722-Antigens, T-Independent,
pubmed-meshheading:8183722-Carotenoids,
pubmed-meshheading:8183722-Dose-Response Relationship, Drug,
pubmed-meshheading:8183722-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8183722-Female,
pubmed-meshheading:8183722-Immunoglobulin G,
pubmed-meshheading:8183722-Immunoglobulin M,
pubmed-meshheading:8183722-Mice,
pubmed-meshheading:8183722-Mice, Inbred C57BL,
pubmed-meshheading:8183722-T-Lymphocytes,
pubmed-meshheading:8183722-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:8183722-Xanthophylls,
pubmed-meshheading:8183722-beta Carotene
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens.
|
| pubmed:affiliation |
Department of Pediatrics, University of Minnesota, Minneapolis 55455.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|