| pubmed-article:8180322 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C0007271 | lld:lifeskim |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C0033687 | lld:lifeskim |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C0497156 | lld:lifeskim |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8180322 | lifeskim:mentions | umls-concept:C1456501 | lld:lifeskim |
| pubmed-article:8180322 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8180322 | pubmed:dateCreated | 1994-6-16 | lld:pubmed |
| pubmed-article:8180322 | pubmed:abstractText | The chemopreventive action of carotenoids on proteinuria and lymphadenopathy were examined in autoimmune-prone MRL-lpr/lpr (MRL/l) mice. They were fed a synthetic full-fed diet (16-18 kcal/mouse/day) with supplementation of beta-carotene or astaxanthin (0.19 mumoles/mouse, 3 times a week), and the development of lymphadenopathy and proteinuria were examined. MRL/l mice fed a full-fed diet without the supplementation of carotenoids or those fed a calorie-restricted (CR) diet (10-11 kcal/mouse/day, 60% calorie intake of full-fed mice) were employed as controls. CR dramatically delayed the development of proteinuria and lymphadenopathy, as reported previously. Carotenoids also significantly delayed the onset of these symptoms in MRL/l mice fed a full-fed diet. Carotenoids were half as effective as CR and astaxanthin, a carotenoid without provitamin A activity, which appeared to exert more significant preventive actions than beta-carotene in delaying the development of these symptoms. Similar chemopreventive actions of carotenoids were also demonstrated in MRL/l mice fed a regular diet (Lab Chow). CR has been shown to augment IL-2 production and to decrease serum prolactin levels in this strain, which may be related to its dramatic preventive action of autoimmunity. However, carotenoids did not affect IL-2 production nor prolactin levels in full-fed MRL/l mice. The chemopreventive actions of carotenoids observed in autoimmune-prone MRL/l mice may be attributed to yet unknown mechanisms, apart from their provitamin A activity or oxygen-quenching activity. | lld:pubmed |
| pubmed-article:8180322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8180322 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8180322 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8180322 | pubmed:issn | 0891-6934 | lld:pubmed |
| pubmed-article:8180322 | pubmed:author | pubmed-author:GoodR ARA | lld:pubmed |
| pubmed-article:8180322 | pubmed:author | pubmed-author:TomitaYY | lld:pubmed |
| pubmed-article:8180322 | pubmed:author | pubmed-author:DayN KNK | lld:pubmed |
| pubmed-article:8180322 | pubmed:author | pubmed-author:EngelmanR WRW | lld:pubmed |
| pubmed-article:8180322 | pubmed:author | pubmed-author:JyonouchiHH | lld:pubmed |
| pubmed-article:8180322 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8180322 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:8180322 | pubmed:geneSymbol | lpr | lld:pubmed |
| pubmed-article:8180322 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8180322 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8180322 | pubmed:pagination | 95-102 | lld:pubmed |
| pubmed-article:8180322 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
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| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:meshHeading | pubmed-meshheading:8180322-... | lld:pubmed |
| pubmed-article:8180322 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8180322 | pubmed:articleTitle | Preventive action of carotenoids on the development of lymphadenopathy and proteinuria in MRL-lpr/lpr mice. | lld:pubmed |
| pubmed-article:8180322 | pubmed:affiliation | Department of Public Health, School of Medicine, Kurume University, Japan. | lld:pubmed |
| pubmed-article:8180322 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8180322 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8180322 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8180322 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14102 | entrezgene:pubmed | pubmed-article:8180322 | lld:entrezgene |
