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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-6-16
|
| pubmed:abstractText |
The chemopreventive action of carotenoids on proteinuria and lymphadenopathy were examined in autoimmune-prone MRL-lpr/lpr (MRL/l) mice. They were fed a synthetic full-fed diet (16-18 kcal/mouse/day) with supplementation of beta-carotene or astaxanthin (0.19 mumoles/mouse, 3 times a week), and the development of lymphadenopathy and proteinuria were examined. MRL/l mice fed a full-fed diet without the supplementation of carotenoids or those fed a calorie-restricted (CR) diet (10-11 kcal/mouse/day, 60% calorie intake of full-fed mice) were employed as controls. CR dramatically delayed the development of proteinuria and lymphadenopathy, as reported previously. Carotenoids also significantly delayed the onset of these symptoms in MRL/l mice fed a full-fed diet. Carotenoids were half as effective as CR and astaxanthin, a carotenoid without provitamin A activity, which appeared to exert more significant preventive actions than beta-carotene in delaying the development of these symptoms. Similar chemopreventive actions of carotenoids were also demonstrated in MRL/l mice fed a regular diet (Lab Chow). CR has been shown to augment IL-2 production and to decrease serum prolactin levels in this strain, which may be related to its dramatic preventive action of autoimmunity. However, carotenoids did not affect IL-2 production nor prolactin levels in full-fed MRL/l mice. The chemopreventive actions of carotenoids observed in autoimmune-prone MRL/l mice may be attributed to yet unknown mechanisms, apart from their provitamin A activity or oxygen-quenching activity.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carotenoids,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthophylls,
http://linkedlifedata.com/resource/pubmed/chemical/astaxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/beta Carotene
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0891-6934
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:geneSymbol |
lpr
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
95-102
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8180322-Animals,
pubmed-meshheading:8180322-Autoimmune Diseases,
pubmed-meshheading:8180322-Body Weight,
pubmed-meshheading:8180322-Carotenoids,
pubmed-meshheading:8180322-Diet, Reducing,
pubmed-meshheading:8180322-Energy Intake,
pubmed-meshheading:8180322-Female,
pubmed-meshheading:8180322-Food, Fortified,
pubmed-meshheading:8180322-Interleukin-2,
pubmed-meshheading:8180322-Lymph Nodes,
pubmed-meshheading:8180322-Lymphocyte Activation,
pubmed-meshheading:8180322-Lymphoproliferative Disorders,
pubmed-meshheading:8180322-Mice,
pubmed-meshheading:8180322-Mice, Mutant Strains,
pubmed-meshheading:8180322-Organ Size,
pubmed-meshheading:8180322-Prolactin,
pubmed-meshheading:8180322-Proteinuria,
pubmed-meshheading:8180322-T-Lymphocytes,
pubmed-meshheading:8180322-Xanthophylls,
pubmed-meshheading:8180322-beta Carotene
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Preventive action of carotenoids on the development of lymphadenopathy and proteinuria in MRL-lpr/lpr mice.
|
| pubmed:affiliation |
Department of Public Health, School of Medicine, Kurume University, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|