|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0036849,
umls-concept:C0067033,
umls-concept:C0205225,
umls-concept:C0439677,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1171362,
umls-concept:C1442518,
umls-concept:C1511938,
umls-concept:C1515670,
umls-concept:C1533691,
umls-concept:C1552652,
umls-concept:C1552685,
umls-concept:C1704632,
umls-concept:C1705195,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1994-6-3
|
|
pubmed:abstractText |
Regulation of myeloblastin expression was studied during myeloid differentiation of HL60 cells and compared with that of myeloperoxidase. Induction towards the monocytic pathway of differentiation caused a rapid, marked and parallel down-regulation of both transcripts which were insensitive to cycloheximide. Thus, myeloblastin is directly regulated and, similarly to myeloperoxidase, belongs to the set of primary response genes. Nuclear run-on experiments and RNA half-life determinations revealed that myeloblastin regulation was at both the transcriptional and posttranscriptional levels.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
200
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1130-5
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8179593-Base Sequence,
pubmed-meshheading:8179593-Cell Differentiation,
pubmed-meshheading:8179593-Cell Line,
pubmed-meshheading:8179593-DNA, Complementary,
pubmed-meshheading:8179593-Gene Expression Regulation,
pubmed-meshheading:8179593-Genetic Markers,
pubmed-meshheading:8179593-Granulocytes,
pubmed-meshheading:8179593-Hematopoiesis,
pubmed-meshheading:8179593-Humans,
pubmed-meshheading:8179593-Molecular Sequence Data,
pubmed-meshheading:8179593-Monocytes,
pubmed-meshheading:8179593-Myeloblastin,
pubmed-meshheading:8179593-Peroxidase,
pubmed-meshheading:8179593-RNA, Messenger,
pubmed-meshheading:8179593-Serine Endopeptidases,
pubmed-meshheading:8179593-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8179593-Transcription, Genetic
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Myeloblastin/proteinase 3 belongs to the set of negatively regulated primary response genes expressed during in vitro myeloid differentiation.
|
|
pubmed:affiliation |
Laboratory for Clinical and Experimental Research, University of Berne, Switzerland.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
