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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-6
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pubmed:abstractText |
Oral administration of isotretinoin (13-cis-retinoic acid) (6 mg/kg per day), 0.05% hexachlorobenzene (HCB) or both drugs simultaneously for 10 days to female Wistar rats caused a statistically significant induction of aminopyrine-N-demethylase (ADM), 7-ethoxyresorufin-O-deethylase (7-ERO-D) and erythromycin-N-demethylase (EMDM) in the liver microsomes. Oral administration of isotretinoin alone or together with HCB induced a marked induction of 7-ERO-D and EMDM in the skin. Administration of isotretinoin alone for 60 days resulted in the induction of EMDM in the liver microsomes, and in combination with HCB caused a statistically significant induction of all hepatic isozymes. HCB alone caused a marked induction of only 7-ERO-D in the skin. These results clearly show that oral isotretinoin is capable of inducing hepatic and cutaneous microsomal P-450-dependent catalytic activities. It remains to be elucidated whether the induction of these enzymes is of importance for the therapeutic action of isotretinoin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aminopyrine N-Demethylase,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Hexachlorobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Isotretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, N-Demethylating
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pubmed:status |
MEDLINE
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pubmed:issn |
0340-3696
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
104-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8154922-Aminopyrine N-Demethylase,
pubmed-meshheading:8154922-Animals,
pubmed-meshheading:8154922-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:8154922-Cytochrome P-450 CYP1A1,
pubmed-meshheading:8154922-Cytochrome P-450 CYP3A,
pubmed-meshheading:8154922-Cytochrome P-450 Enzyme System,
pubmed-meshheading:8154922-Enzyme Induction,
pubmed-meshheading:8154922-Female,
pubmed-meshheading:8154922-Hexachlorobenzene,
pubmed-meshheading:8154922-Isoenzymes,
pubmed-meshheading:8154922-Isotretinoin,
pubmed-meshheading:8154922-Liver,
pubmed-meshheading:8154922-Microsomes, Liver,
pubmed-meshheading:8154922-Oxidoreductases,
pubmed-meshheading:8154922-Oxidoreductases, N-Demethylating,
pubmed-meshheading:8154922-Rats,
pubmed-meshheading:8154922-Rats, Wistar,
pubmed-meshheading:8154922-Skin
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pubmed:year |
1994
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pubmed:articleTitle |
Influence of oral isotretinoin on hepatic and cutaneous P-450-dependent isozyme activities.
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pubmed:affiliation |
Department of Dermatology, Heinrich-Heine University, Düsseldorf, Germany.
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pubmed:publicationType |
Journal Article
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