Linked Life Data

8132634

Source:http://linkedlifedata.com/resource/pubmed/id/8132634

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1994-4-21
pubmed:abstractText
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and renal tubular epithelial cells and may play an important role in regeneration following hepatic and renal injury. HGF is first synthesized as a single chain precursor which is then converted to a heterodimeric form by proteolytic processing. This proteolytic conversion is required for HGF to function as a mitogen. In this study, we examined whether the proteolytic activation of HGF occurred in response to hepatic and renal injury. HGF remained as an inactive single chain form in the liver, kidney, lung, and spleen of normal rats. The production of HGF markedly increased in the liver after hepatotoxin treatment and in the kidney after nephrotoxin treatment. A significant portion of the increased HGF was converted to the active heterodimeric form, whereas in other tissues, conversion did not occur although the production of HGF increased in some of them. Furthermore, an enzymatic activity that converts the single chain form of HGF to the active heterodimeric form was detected in the injured liver but not in the normal liver. These results indicate that HGF is proteolytically activated in response to tissue injury, and this activation is mediated by an enzymatic activity which is induced exclusively in the injured tissues. Thus, the proteolytic activation system functions in vivo as a mechanism for localizing HGF activities to injured tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
269
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8966-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Proteolytic activation of hepatocyte growth factor in response to tissue injury.
pubmed:affiliation
Institute for Liver Research, Kansai Medical University, Osaka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't