Linked Life Data

8125264

Source:http://linkedlifedata.com/resource/pubmed/id/8125264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1994-4-12
pubmed:abstractText
We have demonstrated that the expression of the ELP in our strains is the outcome of a genetically determined, environmentally modulated, event dependent, developmental process. Given the appropriate genetic and environmental conditions, we observe an early acting temporal progression of alterations in specific gene activity patterns which appear to give rise to functional phenotypic changes. The observed patterns are consistent with the interpretations drawn from our chromosome substitution and biomarker experiments. The interaction of specific environmental and genetic factors is sufficient to explain the observed plasticity of longevity in our L strain. Independently derived long lived strains may have altered different combinations of physiological mechanisms so as to give rise to a statistically equivalent ELP. Theoretically based conclusions obtained from only one set of sister strains may be difficult to extrapolate to other strains. Future work will involve the experimental verification of the genetic-environmental circuitry discussed here, using novel molecular genetic techniques to define, characterize, and isolate the genes involved in the expression of the ELP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0016-6707
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain of Drosophila.
pubmed:affiliation
Department of Biological Sciences, Wayne State University, Detroit, MI 48202.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't