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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-3-23
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pubmed:abstractText |
Models of acute and chronic candidiasis were developed in Fischer 344 rats to evaluate the therapeutic efficacy of recombinant human macrophage colony-stimulating factor (rhM-CSF) alone and in combination with the antifungal agent fluconazole. In the acute model, rats were challenged by intravenous injection with 2 x 10(6) Candida albicans, approximately 4 times the LD50. Daily subcutaneous (sc) bolus injections of rhM-CSF for 10 days plus a single sc bolus dose of 0.3 mg/kg of fluconazole improved the median survival time from 5 days (32% survival) with fluconazole alone to > 30 days (88% survival) in the rhM-CSF- and fluconazole-treated rats. In the chronic model, daily sc bolus injections of rhM-CSF for 10 days plus a single sc bolus dose of 1.0 mg/kg of fluconazole decreased the median titer of C. albicans cultured from the kidneys by 10-fold at 15 and 30 days after infection. These studies showed that rhM-CSF treatment improved the therapeutic outcome in both the acute and chronic rat model of candidiasis when used with fluconazole, a standard fungistatic agent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
369-74
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8106770-Acute Disease,
pubmed-meshheading:8106770-Animals,
pubmed-meshheading:8106770-Candidiasis,
pubmed-meshheading:8106770-Chronic Disease,
pubmed-meshheading:8106770-Fluconazole,
pubmed-meshheading:8106770-Leukocyte Count,
pubmed-meshheading:8106770-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:8106770-Male,
pubmed-meshheading:8106770-Rats,
pubmed-meshheading:8106770-Rats, Inbred F344,
pubmed-meshheading:8106770-Recombinant Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Antifungal activity of recombinant human macrophage colony-stimulating factor in models of acute and chronic candidiasis in the rat.
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pubmed:affiliation |
Department of Pharmacology, Chiron Corp., Emeryville, California 94608-2916.
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pubmed:publicationType |
Journal Article
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