Linked Life Data

8106190

Source:http://linkedlifedata.com/resource/pubmed/id/8106190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-3-23
pubmed:abstractText
Dogs infected with a pathogenic Trypanosoma cruzi isolate (Tc-O), or a non-pathogenic isolate (Tc-D) developed low antinuclear antibody titers throughout 240 days of infection. Dogs infected with Tc-O, but not Tc-D, produced anti-heart tissue antibodies (as measured by an ELISA) throughout infection. Antibody levels were highest immediately after the acute stage of infection (30 days post-inoculation--DPI) when myocardiocyte destruction was at its greatest. Antibody levels progressively declined by 100 DPI, and were almost undetectable by 240 DPI when Tc-O infected dogs developed dilated cardiomyopathy. On Western blots, the anti-heart tissue antibodies recognized an antigen with the same molecular weights (65 and 61 kDa M(r)) recognized by a monoclonal antibody against human beta-adrenoceptors. The results suggest that dogs produce antibodies against heart tissue antigens, possibly the beta-adrenoceptor, during infection with a pathogenic, but not a non-pathogenic, isolate of T. cruzi.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0020-7519
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
961-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Anti-heart tissue antibodies during experimental infections with pathogenic and non-pathogenic Trypanosoma cruzi isolates in dogs.
pubmed:affiliation
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850.
pubmed:publicationType
Journal Article