Linked Life Data

8105875

Source:http://linkedlifedata.com/resource/pubmed/id/8105875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-12-17
pubmed:abstractText
The Drosophila homeotic gene Abdominal-B includes two genetically distinct elements, a morphogenetic (m) activity and a regulatory (r) activity. The proteins responsible for these activities were ectopically expressed in fly embryos. The larval cuticular transformations which result are consistent with the genetically defined role of each protein during normal embryogenesis. Both ABD-B proteins activate ectopic expression of transcripts encoding the m protein, but the levels of Antennapedia, Ultrabithorax and abdominal-A transcripts are differentially repressed. A structural and functional comparison of the ABD-B proteins and a chimeric DFD/ABD-B protein reaffirms that target specificity is largely determined by the homeodomain region and suggests protein domains outside of the homeodomain influence the activation or repression of target gene expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:geneSymbol
Abd-B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-37
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Abdominal-B protein isoforms exhibit distinct cuticular transformations and regulatory activities when ectopically expressed in Drosophila embryos.
pubmed:affiliation
Department of Biological Sciences, University of Pittsburgh, PA 15260.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.