Linked Life Data

8104720

Source:http://linkedlifedata.com/resource/pubmed/id/8104720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-5
pubmed:abstractText
A monoclonal antibody, NCL-CB11, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded breast neoplasm biopsies. Sixty-five out of 115 infiltrating ductal carcinoma, eleven out of 15 intraductal carcinoma and seventeen out of 22 mammary Paget's diseases exhibited positive membrane staining, indicating amplification of the gene in these tumours. In infiltrating ductal carcinoma, there was a positive correlation between c-erbB-2 overexpression and axillary lymph node metastasis as well as between the overexpression and the number of mitotic figures. These results suggest that c-erbB-2 expression might be used as a predictive marker for the worse prognosis of breast carcinoma. The significance of c-erbB-2 expression in other malignant tumours and benign lesions is also discussed.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0529-5807
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Study of c-erbB-2 expression in breast neoplasms].
pubmed:affiliation
Department of Pathology, Affiliated Hospital, Guangdong Medical College, Zhanjiang.
pubmed:publicationType
Journal Article, English Abstract