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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1993-9-30
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pubmed:abstractText |
We have studied in situ the excitability state of the axon-soma membrane of CA1 pyramidal cells in the rat during synaptic activation of N-methyl-D-aspartate (NMDA) receptors. Repetitive activation (3-5 Hz) of Schaffer collaterals provoked a NMDA receptor-mediated component in the field excitatory postsynaptic potential (fEPSP) within 15 s. The generation of this component follows a characteristic self-limiting cycle, vanishing after 6-10 s. When alvear shocks were paired to the orthodromic volleys, the antidromic population spike (PS) was completely abolished only if the NMDA receptor-mediated fEPSP had occurred. This blockade of antidromic invasion lasted for 120-150 ms after each orthodromic shock. A reduction in the safety factor for axon-soma transmission is presumed during NMDA receptor synaptic activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
616
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8102941-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:8102941-Animals,
pubmed-meshheading:8102941-Axons,
pubmed-meshheading:8102941-Electric Stimulation,
pubmed-meshheading:8102941-Evoked Potentials,
pubmed-meshheading:8102941-Hippocampus,
pubmed-meshheading:8102941-Piperazines,
pubmed-meshheading:8102941-Pyramidal Tracts,
pubmed-meshheading:8102941-Quinoxalines,
pubmed-meshheading:8102941-Rats,
pubmed-meshheading:8102941-Rats, Sprague-Dawley,
pubmed-meshheading:8102941-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8102941-Stereotaxic Techniques,
pubmed-meshheading:8102941-Synapses,
pubmed-meshheading:8102941-Time Factors
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pubmed:year |
1993
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pubmed:articleTitle |
Blockade of antidromic invasion of CA1 pyramidal cells during synaptic activation of NMDA receptors.
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pubmed:affiliation |
Dept. Investigación, Hospital Ramón y Cajal, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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