Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-7-23
pubmed:abstractText
Transgenic expression of interleukin 10 (IL-10) in the islets of Langerhans leads to a pronounced pancreatic inflammation, without inflammation of the islets of Langerhans and without diabetes. A scattered infiltration of macrophages (M pi) precedes localized accumulations of CD4+ and CD8+ T lymphocytes, B lymphocytes, and M pi. This recruitment of inflammatory cells to the pancreas is somewhat surprising, since the biological activities of IL-10 in vitro indicate that IL-10 is a powerful immunosuppressive cytokine. Since endothelial cells play a major role in leukocyte extravasation, we examined if vascular changes and extralymphoid induction of peripheral and mucosal type vascular addressins contributed to IL-10-induced homing of mononuclear cells to the pancreas. The endothelium lining small vessels was highly activated in areas of inflammation, as the endothelial cells became cuboidal, and exhibited increased expression of major histocompatibility complex class II (Ia), intercellular adhesion molecule 1, and von Willebrand Factor. Furthermore, induction of vascular addressins simultaneously with accumulation of mononuclear cells around islets and vessels indicated that the endothelial cells take on the phenotype of differentiated endothelium specialized for leukocyte extravasation. In conclusion, pancreatic inflammation and vascular changes are prominent in IL-10 transgenic mice. We hypothesize that IL-10, in addition to its immuno-inhibitory properties, is a potent recruitment signal for leukocyte migration in vivo. These effects are relevant for in vivo therapeutic applications of IL-10.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1356125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1418706, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1418711, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1528880, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1541819, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1590996, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1674689, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1674735, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1686177, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1695646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1697308, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1697486, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1697876, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1712790, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1769695, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1827484, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1906502, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-1940369, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2046401, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2105107, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2107253, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2118234, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2123224, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2124236, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2161559, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2449974, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2610269, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2656351, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2666213, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2670559, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-2911352, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-3097642, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-3584977, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-3726548, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-4045596, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-6651893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-6884423, http://linkedlifedata.com/resource/pubmed/commentcorrection/8100268-8419468
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-85
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.
pubmed:affiliation
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't