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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0017262,
umls-concept:C0069515,
umls-concept:C0185117,
umls-concept:C0205160,
umls-concept:C0220901,
umls-concept:C0237881,
umls-concept:C0746922,
umls-concept:C0750502,
umls-concept:C1704824,
umls-concept:C1706163,
umls-concept:C2697524,
umls-concept:C2700445,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1993-4-1
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pubmed:abstractText |
The prognostic value of c-erbB-2 oncogene expression was studied retrospectively in a consecutive series of 230 node negative breast cancers, followed-up for at least 7 years after primary treatment. The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method. Positive immunostaining was observed in 20.9% of cases, whereas strong diffuse positivity was recorded only in 8.7% of cases. C-erbB-2 gene product showed no association to T category or nuclear grade. A significant association of c-erbB-2 expression to prognosis was observed only for cases showing a strong diffuse immunostaining, but such an association was no longer statistically significant at multivariate analysis adjusting for other prognostic factors such as T category and nuclear grading. C-erbB-2 expression is of no value to predict the clinical course of node negative patients in the current practice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-13442910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1672251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1672253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1672255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1672872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1967301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1979454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-1988136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2189998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2342630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2569032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2849974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2849975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2893663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2903446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-2999974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-3226722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-3330785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-3474361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-3798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8094977-7443307
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
625-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8094977-Adult,
pubmed-meshheading:8094977-Breast Neoplasms,
pubmed-meshheading:8094977-Female,
pubmed-meshheading:8094977-Humans,
pubmed-meshheading:8094977-Middle Aged,
pubmed-meshheading:8094977-Prognosis,
pubmed-meshheading:8094977-Proto-Oncogene Proteins,
pubmed-meshheading:8094977-Receptor, erbB-2,
pubmed-meshheading:8094977-Retrospective Studies,
pubmed-meshheading:8094977-Survival Analysis
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pubmed:year |
1993
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pubmed:articleTitle |
Prognostic significance of c-erbB-2 expression in node negative breast cancer.
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pubmed:affiliation |
University Institute of Anatomia e Istologia Patologica, Florence, Italy.
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pubmed:publicationType |
Journal Article
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